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The major evaluation of effi cacy was primarily based on the assessments of response and condition progression for every single affected person by the independent response evaluation panel, members of which have been masked to therapy assignment.

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The primary examination of effi cacy was based mostly on the assessments of response and condition progression for each and every patient by the independent response review panel, members of which were masked to therapy assignment. Response requirements and progression were assessed according to the Nationwide Cancer Institute Functioning Groups 1996 guidelines for CLL, requirements for condition progression were specifi ed in the examine protocol and were in accordance with these guidelines.

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The amount of CD4 CD25bright T cells infused with the graft is not identified. Cyclosporine A, which experienced been used to take care of signs and symptoms, was ongoing for graft vs. host illness prophylaxis. Palifermin was administered every day for three days preceding to the start of the preparative routine and three days after the stem cell infusion for mucositis avoidance and gastrointestinal safety.